Estradiol Can Help Protect Against Atherosclerosis During Menopause

28. Oktober 2025

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The American Heart Association presented the results of a study on the effectiveness of hormone replacement therapy and its impact on the heart health of postmenopausal women. The scientists' conclusions are unambiguous: if you want to keep your heart healthy, you should not postpone taking hormones.

Wichtigste Erkenntnisse

The American Heart Association presented the results of a study on the effectiveness of hormone replacement therapy and its impact on the heart health of postmenopausal women.
Why does the body need estradiol?
Evidence base

Für wen das ist

Für alle, die Hormone und Schilddrüse über atherosklerose, herz erkunden.

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Darya

Autor, Ornament

If you start taking estradiol within six years of menopause, the risk of developing and progressing atherosclerosis is significantly reduced, but starting estradiol therapy ten years after menopause no longer has similar benefits, says research presented at the American Heart Association's 2020 Scientific Session on Epidemiology and Prevention and Cardiometabolic Health.

Why does the body need estradiol?

Estradiol is a female sex hormone, a form of estrogen that is often prescribed to treat menopausal symptoms and prevent atherosclerosis. With the onset of menopause, its level in the body decreases dramatically.

Evidence base

Researchers analyzed the results of an early and late intervention study using estradiol that included 643 healthy postmenopausal women. The results showed that women who started hormone therapy earlier had less arterial wall thickening due to cholesterol compared to those who started hormone therapy later or received a placebo.

"Atherosclerosis is a major cause of cardiovascular disease," says lead study author Roxanne Karim, M.D., associate professor of clinical preventive medicine at the Keck School of Medicine at the University of Southern California in Los Angeles. "Our results show that the earlier a woman starts getting estradiol during menopause, the less cholesterol accumulates in her arteries."

Sources: https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/menopause-and-heart-disease

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