Melatonin Can Reduce Creatinine and Prevent the Progression of Kidney Disease

28 de octubre de 2025

1 min de lectura

Researchers from the University of Granada, Universitario La Paz Hospital, and the University of Texas in the US have taken an important step in the fight against kidney damage and renal failure.

Puntos clave

Researchers from the University of Granada, Universitario La Paz Hospital, and the University of Texas in the US have taken an important step in the fight against kidney damage and renal failure.
Initial melatonin research
Evidence base

Para quién es

Personas que exploran Riñón a través de melatonina, riñón.

Por qué importa

Este artículo te ayuda a orientarte rápidamente y luego avanzar a una colección o serie si quieres seguir profundizando.

Autor del artículo

Darya

Escritora, Ornament

In two new studies recently published in the Journal of Clinical Medicine and Pharmacy, the researchers proved that regular administration of melatonin at doses of 10 mg/kg body weight per day prevents damage to kidney cells (nephrons) and the development of renal failure.

Initial melatonin research

This research began 10 years ago when these same scientists investigated the effects of melatonin on the body as part of research into circadian rhythms and the development of sleep regulators. An unexpected effect they found was that melatonin reduced the increased production of free oxygen radicals (responsible for oxidative stress). Since then, other studies have shown that abnormally high oxidative stress leads to loss of kidney function, development of renal failure, and the need for hemodialysis or transplantation.

Evidence base

Based on these findings, scientists have conducted experiments on mice, and the results were more than convincing: the systematic administration of melatonin in experimental mice decreased damage to nephrons, decreased creatinine (a better marker of kidney function), and improved kidney structure.

According to Ahmad Agil, the lead author of this study, "Kidney damage can be caused by metabolic complications of obesity, such as diabetes, hypertension, blood lipid metabolism disorders or fatty liver disease.

Our main goal is to find a safe way to slow or stop this process, and melatonin may be the best possible solution. We look forward to approval for a human clinical trial, as there are no side effects or risks in our proposed methodology."

Sources: Ahmad Agil et al, Melatonin Improves Mitochondrial Dynamics and Function in the Kidney of Zücker Diabetic Fatty Rats, Journal of Clinical Medicine (2020). DOI: 10.3390/jcm9092916 Samira Aouichat et al, Melatonin Improves Endoplasmic Reticulum Stress-Mediated IRE1α Pathway in Zücker Diabetic Fatty Rat, Pharmaceuticals (2021). DOI: 10.3390/ph14030232

Seguir leyendo

Riñón#riñón

Es hora de revisar sus riñones: 9 síntomas alarmantes

Cuando notamos un problema de salud, a menudo no entendemos qué lo ha ocasionado. Además, no lo asociamos a una falla en el funcionamiento de algún órgano en particular. ¿A qué síntomas debe prestar atención que sean signos de problemas renales?

Dr. Oleh28 oct 2025

Riñón#riñón

4 Important Questions About Kidney Stones

If left untreated, a kidney stone can grow to the size of a tennis ball, but it will begin to cause serious discomfort much sooner than that. How can you avoid them?

Dr. Alex28 oct 2025

Salud cardiovascular#ataque cardíaco

Even Slightly Elevated Thyroid Hormone Levels Can Cause Sudden Cardiac Arrest

The risk of death from a heart attack was found to be almost equal in patients with severely elevated thyroxine levels and those whose levels were normal but closer to the upper limit.

Darya28 oct 2025

Estilo de vida saludable#swelling

Bags Under Eyes: Causes and Solutions

As we age, the tissues around the eyes tend to weaken, including some of the muscles that support the eyelids. Bags under the eyes are thought to be a cosmetic issue. However, they often indicate serious illnesses.

Dra. Ely28 oct 2025

Instala Ornament para no solo leer estos artículos, sino también hacer seguimiento de tu salud, guardar resultados de análisis y acceder a otras funciones útiles

Instalar Ornament