#bad cholesterol #good cholesterol #alzheimer disease+2

Cholesterol Is the Key to New Treatments for Alzheimer’s Disease and Diabetes

28 octombrie 2025

2 min de lectură

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There is no cure for Alzheimer's disease. Researchers around the world have been trying for decades to find a way to fight this terrible disease, which affects more than 5.5 million people in the United States alone. Gregory Thatcher, professor of medical sciences at the University of Arizona, has published a study that breaks new ground in the treatment of Alzheimer's disease and type 2 diabetes mellitus (DM2).

Concluzii cheie

There is no cure for Alzheimer's disease.
Alzheimer's disease and diabetes: where is the connection?
How does cholesterol affect the brain?

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Autorul articolului

Alina

Editor-in-Chief Ornament Health AG

Alzheimer's disease and diabetes: where is the connection?

In the past decade, scientists have found significant evidence that the causes of DM2 and Alzheimer's disease are related.

DM2 occurs when insulin's effectiveness in removing glucose from the bloodstream is reduced, which leads to high blood sugar levels and can trigger abnormally high cholesterollevels. A similar situation occurs in Alzheimer's disease, but the effect is not on the body as a whole, but on the brain.

Thatcher and his group had the goal of identifying compounds that would counteract the changes in the body that provoke both diseases.

How does cholesterol affect the brain?

When cholesterol levels rise due to insulin resistance or other factors, the body triggers a process known as reverse cholesterol transport, in which certain molecules carry excess cholesterol to the liver for excretion.

Apolipoprotein E (ApoE), a major genetic risk factor for Alzheimer's disease as well as type 2 diabetes, is one of the proteins involved in reverse cholesterol transport.

The decreased activity of another cholesterol transporter, A1 (ABCA1), increases the risk of cardiovascular disease, DM2, and Alzheimer's disease.

An overview of the study

Moving cholesterol to where it is needed in the body has positive effects on many physiological processes and can help get rid of the accumulation of abnormal forms of protein that accumulate in the brain in Alzheimer's disease.

Dr. Thatcher was able to isolate a specific molecule, CL2-57, that can help regulate cholesterol levels in the brain by improving ABCA1 function in the body. The use of this compound has been shown to increase glucose tolerance and insulin sensitivity. One of the positive effects is slower weight gain in patients.

Increased ABCA1 activity is expected to positively affect insulin secretion and reduce inflammation in the brain, offering a chance of curing both DM2 and Alzheimer's disease.

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